MPH
MPH (MINQUE for Partitioning Heritability) is a C++ program for fast REML estimation of genetic (co)variance components.
The method features:
- Effective implementation of Fisher-scoring REML (equivalent to iterative MINQUE)
- Fast and memory-efficient performance
- Robust convergence
- Support for analyses of dominance, epistasis, and genetic correlation
- Capability to perform complex genome-partitioning of quantitative genetic variation and covariation
Citation
Jiang J. MPH: fast REML for large-scale genome partitioning of quantitative genetic variation. Bioinformatics. 2024 May 2;40(5):btae298. doi: 10.1093/bioinformatics/btae298. PMID: 38688661; PMCID: PMC11093526.
License
MPH is distributed under the GPL-3.0 license.
Author and contact
If you want to submit an issue concerning the software, please do so using the MPH GitHub repository.