BFMAP by Jicai Jiang

Bayesian Fine-Mapping and Association for Population and Pedigree Data

BFMAP is a software tool for genomic analysis of quantitative traits, with a focus on fine-mapping, SNP-set association, and functional enrichment. It uses phenotypes and genotypes, and works for samples with population structure and/or relatedness. BFMAP currently supports the following analyses.

• Estimating SNP-heritability;
• Genome-wide single-marker/SNP-set association analysis;
• Fine-mapping by forward selection or shotgun stochastic search;
• Estimating causal-variant enrichment of a functional annotation (i.e., functional enrichment analysis);
• Incorporating functional enrichment into fine-mapping.

---

Manual

---

Download

The executable file is released under the MIT lincense.

---

Example Data

---

Questions and Help Requests

If you have any questions or bug reports, feel free to email Jicai Jiang at jicai_jiang@ncsu.edu.

---

Citation

Jiang, J., Cole, J. B., Freebern, E., Da, Y., VanRaden, P. M., & Ma, L. (2019). Functional annotation and Bayesian fine-mapping reveals candidate genes for important agronomic traits in Holstein bulls. Communications biology, 2(1), 1-12. DOI: 10.1038/s42003-019-0454-y